| Allele Sequence Variations of GABARB1 Locus and Allele Frequency by New Allele Designation in Korean. |
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Hye Rin Lee, Hye Seung Lee, Eun Sub Song, Gil Ro Han, Juck Joon Hwang |
1Department of Legal Medicine, College of Medicine, Korea University, Korea.
2Department of Legal Medicine, Inha University Hospital, Korea. |
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| Abstract |
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To determine allele frequency of GABARB1 Jcus in Korean, first, we sequenced each allele, which was amplified with primers that published before. We found mismatching between allele number and size of each allele when 'GATA' repeats are counted. The sequence revealed new 'GATA' repeat. So we had made new allele designation with total number of in 176 Korean people. The heterozygosity this locus was 0.716 and mean exclusion chance (MEC) and power of discrimination (PD) were 0.433 and 0.845, respectively. In this study, we emphasized necessity of sequencing of 2-3 alleles, which have same size before setting up allelic ladder. |
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