Korean J Leg Med Search


Korean Journal of Legal Medicine 2003;27(2):23-30.
Published online October 31, 2003.
Development of Multi-tissue Array Block for Diagnosis of Early Myocardial Infarction.
Hongil Ha, Zhe Li, Jang Han Kim, Yoon Seong Lee, Jung Bin Lee, Soong Deok Lee
1Department of Forensic Medicine, Seoul National University College of Medicine, Korea. sdlee@snu.ac.kr
2Department of Medical Humanities and Social Sciences, Ulsan University College of Medicine, Kroea.
Tissue array contains hundreds or thousands tissues from different cases, and has been known useful for rapid analysis of markers in a large numbered work. This has mainly been used in investigative purpose, and few has been reported for diagnostic trial. Diagnosis of early myocardial infarction is important in medicolegal field. Immunohistochemical staining using various antibodies has become a popular tool for this purpose, but standardization and reproducibility have been problems. Use of tissue array is promising in this points. We have made two cardiac tissue arrays using 87 different cases and have verified the feasibility of tissue array in forensic field. Experiences and several issues concerning tissue array are discussed.
Key Words: Tissue array, Heart, Early myocardial infarction, Immunohistochemistry


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