Null and Duplicated Alleles of 17 Y-STR Haplotypes in Koreans and Considerations for Forensic Application.

Cho, Nam Soo; Yoo, Seong Yeon; Hwang, Jung Ho; Seong, Ki Min; Chung, Nak Eun; Lee, Won Tae

Original article

Korean Journal of Legal Medicine 2010;34(2):147-151.
Published online November 30, 2010.

Null and Duplicated Alleles of 17 Y-STR Haplotypes in Koreans and Considerations for Forensic Application.

Nam Soo Cho, Seong Yeon Yoo, Jung Ho Hwang, Ki Min Seong, Nak Eun Chung, Won Tae Lee

¹Department of Forensic Medicine, Central District Office, National Institute of Scientific Investigation, Daejeon, Korea.
²Department of forensic Medicine, Eulji University, Daejeon, Korea. wtlee@eulji.ac.kr

Abstract

The analysis of Y chromosome polymorphisms has become common place for the identification of male component in forensic cases. In male/female mixtures of many rape cases, Y-STRs are also very useful for the determination of contributors' number. During the analyses of 17 Y-STR haplotypes for forensic applications using the AmpFlSTR(R) Yfiler(TM) system, a number of null and duplicated alleles (40 out of 2144 subjects) were discovered. Interestingly, two haplotypes should focus the attention on forensic interpretation of Y-STR haplotype profiles, because multiple mutational events at various loci can be interpreted as a wrong mixed or allele drop-out profile.

Key Words: Y chromosome STR, AmpFlSTR(R) Yfiler(TM) system, null allele, duplicated allele, database

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