Korean J Leg Med Search

CLOSE


Korean Journal of Legal Medicine 2011;35(1):22-26.
Published online May 31, 2011.
Chronic-Binge Ethanol Drinking Exacerbates Liver Damage through Oxidative/Nitrosative Stress.
In Hoon Na, Seong Ho Yoo
1Department of Rehabilitation Medicine, Catholic Medical Center, Seoul, Korea.
2Department of Forensic Medicine and Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea. yoosh@snu.ac.kr
Abstract
Chronic binge alcohol drinking is a major cause of liver disease including steatosis, chronic hepatitis, and liver cirrhosis. The purpose of this study is to examine the change of oxidative/nitrosative stress in the chronic-binge ethanol model. Using wildtype (WT) mice, we show that chronic binge alcohol drinking develops steatosis and apoptotic cells. Furthermore, the activities of anti-oxidant and mitochondrial enzymes including catalase (CAT), superoxide dismutase 1 (SOD1) and glutathione peroxidase (GPx) were decreased in chronic binge alcohol-treated mice. Protein nitration was also increased in a chronic-binge group compared to pair-fed control counterpart. These findings suggest that chronic binge alcohol drinking plays a critical role in hepatic injury through oxidative/nitrosative stress.
Key Words: alcohol, oxidative stress, steatosis
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 632 View
  • 8 Download
Related articles in Korean J Leg Med


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
Institute of Forensic Medicine and Department of Forensic Medicine, Seoul National University College of Medicine
103 Daehak-ro, Jongno-gu, Seoul 03080, Korea
Tel: +82-2-740-8360    Fax: +82-2-902-8340    E-mail: yoosh@snu.ac.kr                

Copyright © 2024 by The Korean Society for Legal Medicine.

Developed in M2PI

Close layer
prev next