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Korean Journal of Legal Medicine 2011;35(1):22-26.
Published online May 31, 2011.
Chronic-Binge Ethanol Drinking Exacerbates Liver Damage through Oxidative/Nitrosative Stress.
In Hoon Na, Seong Ho Yoo
1Department of Rehabilitation Medicine, Catholic Medical Center, Seoul, Korea.
2Department of Forensic Medicine and Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea. yoosh@snu.ac.kr
Chronic binge alcohol drinking is a major cause of liver disease including steatosis, chronic hepatitis, and liver cirrhosis. The purpose of this study is to examine the change of oxidative/nitrosative stress in the chronic-binge ethanol model. Using wildtype (WT) mice, we show that chronic binge alcohol drinking develops steatosis and apoptotic cells. Furthermore, the activities of anti-oxidant and mitochondrial enzymes including catalase (CAT), superoxide dismutase 1 (SOD1) and glutathione peroxidase (GPx) were decreased in chronic binge alcohol-treated mice. Protein nitration was also increased in a chronic-binge group compared to pair-fed control counterpart. These findings suggest that chronic binge alcohol drinking plays a critical role in hepatic injury through oxidative/nitrosative stress.
Key Words: alcohol, oxidative stress, steatosis
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