| A Study on the Effect of Penicillin to the Agglutination Activity of Phytagglutinin, Sophora japonica L. |
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Heung Won Park |
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Department of Legal Medicine, Korea University, College of Medicine, Seoul, Korea |
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| Abstract |
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After Stillmark's report on the agglutination of human and animal red blood cell by extracts of plant, Ricinus communis, numerous studies on phytagglutinin were performed.
Phytagglutinins are divided into non-specific phytagglutinin, race-specific phytagglutinin, and type-specific phytagglutinin.
In Korea, studies of phytagglutinins using Korean native plants were achieved widely and deeply by Moon et al. since 1968.
So, the author performed the agglutination test with human RBC by using seed extract of Sophora japonica L., native to Korea, and studied on the change of agglutination activity of same material treated with various penicillin preparatives.
The seed extracts of Sophora japonica L. react with human RBC as panphytagglutinin, and the results by using that of penicillin treated could be summarized as follows;
1. Human RBC could be divided into 2 groups by agglutination of extract of S. japonica L. treated with penicillin G natrium. In one group, agglutination was inhibited by penicillin specifically(18%), and not in the other group (82%).
2. Penicillin G natrium showed the most stable and repeatable agglutination inhibition reaction among the penicillin preparatives used in the study.
3. The agglutination inhibition property of penicillin to phytagglutinin, S. japonica L , had relation with ABO and H blood types. |
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