A Study on Distribution of Cl Type in Healthy and Sick Individuals

, Eui U Park

Original Article

Korean Journal of Legal Medicine 1986;10(1):26-32.

Department of Legal Medicine, Korea University, College of Medicine, Seoul, Korea

Abstract

It is well established that seed extracts (lectins) are used as diagnostic reagents for blood grouping and for biochemical studies. Moon and Wiener succeded in fractionating a potent anti-Cl lectin from extracts of seeds of Korean Clerodendron trichotomum Thunberg.1) Thereafter, not only nature and distribution of Cl blood type but also distribution in animal blood and secretor status in human saliva were also reported by Moon et al.3)4) During the past years, hundreds of reports have been published on distributions of blood groups among patients with such conditions as schizophrenia(dementia praecox), general paresis, rheumatic fever, epilepsy, longevity, arteriosclerosis, poliomyelitis, hypertension, gastric and duodenal ulcers, stomach cancer, pernicious anemia, and many others.2) It is this respect that the author is interested in the subject. The purpose of the present paper is to consider association between CI blood type and susceptibility to diseases. The material used consisted of anti-Cl lectin extracted from seeds of the Korean Clerodendron trichotomum Thunberg absorbed with Cl negative red cells and 5 per cent red cell suspension collected from many kinds of patients. The technique employed was agglutination test essentially the same as that described by Rhee et al.3) The experiments yielded the following results: 1. In 779 specimens of red blood cells of healthy individuals, the frequency of Cl positive type was 67 per cent and that of Cl negative type was 33 per cent. 2. There were no significant sexual differences in the distribution of Cl blood type of healthy individuals. However, higher frequency of Cl positive type (80 per cent, Z score=3.7475 ) was noted which compared with that of healthy individuals. 3. In the experiment on a series of 1,089 blood specimens of various patients, lower frequency in Cl negative type was noted in patients of viral hepatitis and those of pneumonia.